Structure-Activity Relation of NH2-terminal Human Parathyroid Hormone Fragments
نویسندگان
چکیده
منابع مشابه
Calcium-dependent release of N-terminal fragments and intact immunoreactive parathyroid hormone by human pathological parathyroid tissue in vitro.
The regulation of PTH secretion by extracellular calcium was studied in parathyroid tissue obtained from patients with hyperparathyroidism (adenoma or hyperplasia) using both an amino (N)-terminal RIA as well as an immunoradiometric assay (intact assay) specific for the intact hormone. The parathyroid glands separated into three major groups when examined in terms of absolute amounts of PTH sec...
متن کاملCharacterization of Parathyroid Hormone Fragments Produced
Cleavage of parathyroid hormone by cathepsin D was studied. Four primary products were detected and separated by high performance liquid chromatography. Two of the fragments are fluorescent and therefore contain residue 23 (tryptophan). These fragments are NHderminal in origin. The other two cross-react with antisera directed against COOH-terminal portions of the hormone; they are the complemen...
متن کاملAddressing the tertiary structure of human parathyroid hormone-(1-34).
Parathyroid hormone (PTH) regulates mineral metabolism and bone turnover by activating specific receptors located on osteoblastic and renal tubular cells and is fully functional as the N-terminal 1-34 fragment, PTH-(1-34). Previously, a "U-shaped" conformation with N- and C-terminal helices brought in close proximity by a turn has been postulated. The general acceptance of this hypothesis, desp...
متن کاملOpposite effects of calcitriol and paricalcitol on the parathyroid hormone-(1-84)/large carboxy-terminal-parathyroid hormone fragments ratio in patients with stage 5 chronic kidney disease.
BACKGROUND AND OBJECTIVES The effects of calcitriol and paricalcitol on circulating levels of intact parathyroid hormone, parathyroid hormone-(1-84), the large carboxy-terminal-parathyroid hormone fragments, and the parathyroid hormone-(1-84)/carboxy-terminal-parathyroid hormone fragments were studied. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS In the longitudinal study, 31 hemodialysis pa...
متن کاملStimulation of Enzyme Activity by Parathyroid Hormone
Received for publication 26 October 1976 and in revised form 24 January 1977. INTRODUCTION The fat cell adenylate cyclase is a plasma membrane-bound enzyme which is supposed to play a central role in the stimulation of lipolysis by hormones (1). The rat fat cell enzyme reacts to a variety of hormones including catecholamines and peptide hormones such as ACTH, glucagon, and secretin (2-4). By co...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.8.4308